Sequential subagent execution with two-stage review gates for implementation plans. Use when executing multi-task plans in current session, when tasks need fresh subagent context to avoid...
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Define KPIs, build performance dashboards, track metrics, and drive data-driven decisions
spec-driven-dev
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Feature planning with 4 phases - Specify requirements, Design architecture, break into granular Tasks, Implement and Validate. Creates atomic tasks that agents can implement without errors....
Use when implementing any feature or bugfix, before writing implementation code. Enforces RED-GREEN-REFACTOR cycle with strict discipline against rationalization.
Use when implementing any new feature or function. Use when asked to "add tests later". Use when writing code before tests.
defense-in-depth
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Use when invalid data causes failures deep in execution, requiring validation at multiple system layers - validates at every layer data passes through to make bugs structurally impossible
Trace downstream data lineage and impact analysis. Use when the user asks what depends on this data, what breaks if something changes, downstream dependencies, or needs to assess change risk...
chembl-database
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Query ChEMBL's bioactive molecules and drug discovery data. Search compounds by structure/properties, retrieve bioactivity data (IC50, Ki), find inhibitors, perform SAR studies, for medicinal chemistry.
chembl-database
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Query ChEMBL bioactive molecules and drug discovery data. Search compounds by structure/properties, retrieve bioactivity data (IC50, Ki), find inhibitors, perform SAR studies, for medicinal chemistry.
profiling-tables
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Deep-dive data profiling for a specific table. Use when the user asks to profile a table, wants statistics about a dataset, asks about data quality, or needs to understand a table's structure and...
Growth Hacker
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Design and execute growth experiments using lean, data-driven tactics
init
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Initialize warehouse schema discovery. Generates .astro/warehouse.md with all table metadata for instant lookups. Run once per project, refresh when schema changes. Use when user says "/data:init"...
integration-testing
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Designs comprehensive integration testing strategies including API testing, database testing, microservices testing, end-to-end testing, and test automation frameworks. Produces test plans, test...
anndata
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Data structure for annotated matrices in single-cell analysis. Use when working with .h5ad files or integrating with the scverse ecosystem. This is the data format skillโfor analysis workflows use...
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cellxgene-census
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Query the CELLxGENE Census (61M+ cells) programmatically. Use when you need expression data across tissues, diseases, or cell types from the largest curated single-cell atlas. Best for...
anndata
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This skill should be used when working with annotated data matrices in Python, particularly for single-cell genomics analysis, managing experimental measurements with metadata, or handling...
polars
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Fast in-memory DataFrame library for datasets that fit in RAM. Use when pandas is too slow but data still fits in memory. Lazy evaluation, parallel execution, Apache Arrow backend. Best for...
arboreto
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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to...
arboreto
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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to...